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Issue 20, 2014
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Drug delivery systems based on pharmaceutically active ionic liquids and biocompatible poly(lactic acid)

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Abstract

Poly(L-lactic acid) (PLLA) membranes containing pharmaceutically active ionic liquids (API–ILs) have been prepared by using a simple film casting from solvent evaporation method. Several sets of membranes were prepared from two different ionic liquids namely 1-methyl-3-butyl-imidazolium ibuprofenate (C4MImIbu) and lidocainium ibuprofenate (LidIbu) with different API–IL contents. Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Wide-Angle and Small-Angle X-ray Scattering (WAXS and SAXS) revealed the strong influence of both the IL nature and content on the morphology and the crystallinity of the resulting PLLA. At 20 weight%, LidIbu was shown to act as a plasticizer for PLLA and homogeneous membranes were obtained. In contrast, at the same IL content, phase separation occurred using C4MImIbu, resulting in the formation of porous PLLA. An increase of LidIbu content to 50 weight% results also in phase separation. 1H and 1H–13C CP-MAS NMR measurements evidenced the influence of different morphologies and crystallinities on IL mobility. C4MImIbu was found to be highly mobile whereas the mobility of LidIbu was content dependent. At low percent, low mobility was observed while at higher content, two populations with respectively high and low mobility were observed. These PLLA–IL membranes were further tested as drug delivery systems. In accordance with the morphology and mobility obtained, we demonstrated that release kinetics from PLLA membranes can be tuned by the nature and the content of API–ILs. Sustainable release kinetics were obtained with API–IL acting as a plasticizer while the fastest release was obtained with API–IL acting as a porogenic agent.

Graphical abstract: Drug delivery systems based on pharmaceutically active ionic liquids and biocompatible poly(lactic acid)

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Supplementary files

Article information


Submitted
17 Feb 2014
Accepted
10 Mar 2014
First published
15 Apr 2014

J. Mater. Chem. B, 2014,2, 3133-3141
Article type
Paper
Author version available

Drug delivery systems based on pharmaceutically active ionic liquids and biocompatible poly(lactic acid)

C. Jouannin, C. Tourné-Péteilh, V. Darcos, T. Sharkawi, J. Devoisselle, P. Gaveau, P. Dieudonné, A. Vioux and L. Viau, J. Mater. Chem. B, 2014, 2, 3133
DOI: 10.1039/C4TB00264D

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