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Issue 23, 2014
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A polyglycerol–polycaprolactone–polycitric acid copolymer and its self-assembly to produce medium-responsive nanoparticles

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Abstract

A hyperbranched-linear-hyperbranched amphiphile (HLHA) consisting of polyglycerol, polycaprolactone and polycitric acid blocks was synthesized and characterized. The self-assembly of HLHA in aqueous solutions produced nearly monodispersed nanoparticles. The average size of the nanoparticles in aqueous solutions was 120 nm. Spectroscopy and microscopy analysis showed that the nanoparticles change their structure in response to changes in the polarity of the medium in the solution state, so that the hydrophobicity or hydrophilicity of the solvent dominates the structure and properties of the nanoparticles. This property was used to load hydrophobic anticancer drugs inside the nanoparticles and also to deliver them to cancer cells successfully. In addition to the mentioned properties, the efficient uptake and low toxicity enable the prepared nanoparticles to be potential new systems for future cancer therapy.

Graphical abstract: A polyglycerol–polycaprolactone–polycitric acid copolymer and its self-assembly to produce medium-responsive nanoparticles

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Supplementary files

Article information


Submitted
06 Feb 2014
Accepted
11 Mar 2014
First published
11 Mar 2014

J. Mater. Chem. B, 2014,2, 3589-3596
Article type
Paper

A polyglycerol–polycaprolactone–polycitric acid copolymer and its self-assembly to produce medium-responsive nanoparticles

M. Adeli, A. Kakanejadifard, M. Khani, F. Bani, R. Kabiri and M. Sadeghizad, J. Mater. Chem. B, 2014, 2, 3589
DOI: 10.1039/C4TB00201F

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