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Issue 18, 2014
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Thermomechanical properties, antibiotic release, and bioactivity of a sterilized cyclodextrin drug delivery system

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Abstract

Various local drug delivery devices and coatings are being developed as slow, sustained release mechanism for drugs, yet the polymers are typically not evaluated after commercial sterilization techniques. We examine the effect that commercial sterilization techniques have on the physical, mechanical, and drug delivery properties of polyurethane polymers. Specifically we tested cyclodextrin–hexamethyl diisocyanate crosslinked polymers before and after autoclave, ethylene oxide, and gamma radiation sterilization processes. We found that there is no significant change in the properties of polymers sterilized by ethylene oxide and gamma radiation compared to non-sterilized polymers. Polymers sterilized by autoclave showed increased tensile strength (p < 0.0001) compared to non-sterilized polymers. In the release of drugs, which were loaded after the autoclave sterilization process, we observed a prolonged release (p < 0.05) and a prolonged therapeutic effect (p < 0.05) but less drug loading (p < 0.0001) compared to non-sterilized polymers. The change in the release profile and tensile strength in polymers sterilized by autoclave was interpreted as being caused by additional crosslinking from residual, unreacted, or partially-reacted crosslinker contained within the polymer. Autoclaving therefore represents additional thermo-processing to modify rate and dose from polyurethanes and other materials.

Graphical abstract: Thermomechanical properties, antibiotic release, and bioactivity of a sterilized cyclodextrin drug delivery system

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Article information


Submitted
13 Jan 2014
Accepted
18 Mar 2014
First published
19 Mar 2014

J. Mater. Chem. B, 2014,2, 2764-2772
Article type
Paper
Author version available

Thermomechanical properties, antibiotic release, and bioactivity of a sterilized cyclodextrin drug delivery system

J. M. Halpern, C. A. Gormley, M. A. Keech and H. A. von Recum, J. Mater. Chem. B, 2014, 2, 2764
DOI: 10.1039/C4TB00083H

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