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Issue 9, 2014
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Surface functionalized barium sulfate nanoparticles: controlled in situ synthesis and application in bone cement

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Abstract

The controlled synthesis of surface functionalized BaSO4 nanoparticles with a diameter below 50 nm is achieved by combining the in situ generation of SO42− and the use of a difunctional surface modification agent, (2-(methacryloyloxy)ethyldimethyl-(3-sulfopropyl)ammoniumhydroxide (MSAH). Particularly, a pre-decomposition process of the SO42− precursor (S2O82−) is applied to decouple the in situ generation of SO42− and precipitation of BaSO4. As a result, the nucleation and growth of the BaSO4 particles is manipulated, which significantly reduces the particle size. Different combinations of the pre-decomposition time and MSAH/BaCl2 molar ratios showed a remarkable influence on the morphology and surface functionality of the BaSO4 particles. Furthermore, the morphology control by using other difunctional surface modification agents e.g. 3-sulfopropylmethacrylate potassium salt (SMPS) and 2-acrylamido-2-methylpropane sulfonic acid (AMSA) is examined. The MSAH-functionalized BaSO4 nanoparticles, used as s filler in bone cements, effectively improved the bending modulus and compressive strength of the poly (methyl methacrylate), PMMA, bone cements. The bone cement with MSAH-functionalized BaSO4 nanoparticles exhibited good radiopacity. Moreover, in vitro cell culture experiments demonstrated an improved biocompatibility compared to the bare BaSO4 particles. The MSAH-functionalized BaSO4 nanoparticles may be an ideal candidate material as a bone cement filler.

Graphical abstract: Surface functionalized barium sulfate nanoparticles: controlled in situ synthesis and application in bone cement

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Supplementary files

Article information


Submitted
01 Nov 2013
Accepted
27 Nov 2013
First published
28 Nov 2013

J. Mater. Chem. B, 2014,2, 1264-1274
Article type
Paper
Author version available

Surface functionalized barium sulfate nanoparticles: controlled in situ synthesis and application in bone cement

C. Fang, R. Hou, K. Zhou, F. Hua, Y. Cong, J. Zhang, J. Fu and Y. Cheng, J. Mater. Chem. B, 2014, 2, 1264
DOI: 10.1039/C3TB21544J

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