Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 4, 2014
Previous Article Next Article

Carboxy-silane coated iron oxide nanoparticles: a convenient platform for cellular and small animal imaging

Author affiliations

Abstract

This study reports the synthesis of stabilized ultrasmall iron oxide nanoparticles (USPIO) as bimodal probes for magnetic resonance and optical imaging. These nanosystems are based on small iron oxide cores surrounded by a thin polysiloxane shell exhibiting carboxylic acid functions. Thanks to these functions, hybrid particles were obtained by conjugating a fluorophore to the superparamagnetic contrastophore. Such modification allowed us to directly follow these USPIO in cellulo, which provided interesting information about their internalization pathway and cellular distribution upon mitosis. Finally, the efficiency of these systems as probes for bimodal imaging was emphasized by the observation of their in vivo behavior in mice using magnetic resonance and optical imaging.

Graphical abstract: Carboxy-silane coated iron oxide nanoparticles: a convenient platform for cellular and small animal imaging

Back to tab navigation

Supplementary files

Article information


Submitted
21 Oct 2013
Accepted
08 Nov 2013
First published
08 Nov 2013

J. Mater. Chem. B, 2014,2, 387-397
Article type
Paper

Carboxy-silane coated iron oxide nanoparticles: a convenient platform for cellular and small animal imaging

D. Stanicki, S. Boutry, S. Laurent, L. Wacheul, E. Nicolas, D. Crombez, L. Vander Elst, D. L. J. Lafontaine and R. N. Muller, J. Mater. Chem. B, 2014, 2, 387
DOI: 10.1039/C3TB21480J

Social activity

Search articles by author

Spotlight

Advertisements