Jump to main content
Jump to site search

Issue 4, 2014
Previous Article Next Article

Carboxy-silane coated iron oxide nanoparticles: a convenient platform for cellular and small animal imaging

Author affiliations

Abstract

This study reports the synthesis of stabilized ultrasmall iron oxide nanoparticles (USPIO) as bimodal probes for magnetic resonance and optical imaging. These nanosystems are based on small iron oxide cores surrounded by a thin polysiloxane shell exhibiting carboxylic acid functions. Thanks to these functions, hybrid particles were obtained by conjugating a fluorophore to the superparamagnetic contrastophore. Such modification allowed us to directly follow these USPIO in cellulo, which provided interesting information about their internalization pathway and cellular distribution upon mitosis. Finally, the efficiency of these systems as probes for bimodal imaging was emphasized by the observation of their in vivo behavior in mice using magnetic resonance and optical imaging.

Graphical abstract: Carboxy-silane coated iron oxide nanoparticles: a convenient platform for cellular and small animal imaging

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Oct 2013, accepted on 08 Nov 2013 and first published on 08 Nov 2013


Article type: Paper
DOI: 10.1039/C3TB21480J
Citation: J. Mater. Chem. B, 2014,2, 387-397
  •   Request permissions

    Carboxy-silane coated iron oxide nanoparticles: a convenient platform for cellular and small animal imaging

    D. Stanicki, S. Boutry, S. Laurent, L. Wacheul, E. Nicolas, D. Crombez, L. Vander Elst, D. L. J. Lafontaine and R. N. Muller, J. Mater. Chem. B, 2014, 2, 387
    DOI: 10.1039/C3TB21480J

Search articles by author

Spotlight

Advertisements