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Issue 16, 2014
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Development and characterisation of a new bioink for additive tissue manufacturing

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Abstract

Additive manufacturing forms a potential route towards economically viable production of cellular constructs for tissue engineering. Hydrogels are a suitable class of materials for cell delivery and 3D culture, but are generally unsuitable as construction materials. Gelatine-methacrylamide is an example of such a hydrogel system widely used in the field of tissue engineering, e.g. for cartilage and cardiovascular applications. Here we show that by the addition of gellan gum to gelatine-methacrylamide and tailoring salt concentrations, rheological properties such as pseudo-plasticity and yield stress can be optimised towards gel dispensing for additive manufacturing processes. In the hydrogel formulation, salt is partly substituted by mannose to obtain isotonicity and prevent a reduction in cell viability. With this, the potential of this new bioink for additive tissue manufacturing purposes is demonstrated.

Graphical abstract: Development and characterisation of a new bioink for additive tissue manufacturing

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Supplementary files

Article information


Submitted
17 Sep 2013
Accepted
05 Feb 2014
First published
05 Feb 2014

J. Mater. Chem. B, 2014,2, 2282-2289
Article type
Paper

Development and characterisation of a new bioink for additive tissue manufacturing

F. P. W. Melchels, W. J. A. Dhert, D. W. Hutmacher and J. Malda, J. Mater. Chem. B, 2014, 2, 2282
DOI: 10.1039/C3TB21280G

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