Issue 16, 2014

Highly ordered and tunable polyHIPEs by using microfluidics


We demonstrate how to generate highly ordered porous matrices from dextran-methacrylate (DEX-MA) using microfluidics. We use a flow focusing device to inject an aqueous solution of DEX-MA and surfactant to break the flow of an organic solvent (cyclohexane) into monodisperse droplets at a high volume fraction (above 74% v/v) to form an ordered high internal phase emulsion (HIPE). We collect the crystalline HIPE structure and freeze it by gelling. The resulting polyHIPEs are characterized by an interconnected and ordered morphology. The size of pores and interconnects ranges between hundreds and tens of micrometers, respectively. The technique that we describe allows for precise tuning of all the structural parameters of the matrices, including their porosity, the size of the pores and the lumen of interconnects between the pores. The resulting ordered and precisely tailored HIPE gels represent a new class of scaffolds for applications in tissue engineering.

Graphical abstract: Highly ordered and tunable polyHIPEs by using microfluidics

Supplementary files

Article information

Article type
04 Sep 2013
31 Jan 2014
First published
03 Feb 2014
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2014,2, 2290-2300

Highly ordered and tunable polyHIPEs by using microfluidics

M. Costantini, C. Colosi, J. Guzowski, A. Barbetta, J. Jaroszewicz, W. Święszkowski, M. Dentini and P. Garstecki, J. Mater. Chem. B, 2014, 2, 2290 DOI: 10.1039/C3TB21227K

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