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Issue 15, 2014
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Nanoscale engineering of low-fouling surfaces through polydopamine immobilisation of zwitterionic peptides

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Abstract

We report a versatile approach for the design of substrate-independent low-fouling surfaces via mussel-inspired immobilisation of zwitterionic peptides. Using mussel-inspired polydopamine (PDA) coatings, zwitterionic glutamic acid- and lysine-based peptides were immobilised on various substrates, including noble metals, metal oxides, polymers, and semiconductors. The variation of surface chemistry and surface wettability upon surface treatment was monitored with X-ray photoelectron spectroscopy (XPS) and water contact angle measurements. Following peptide immobilisation, the surfaces became more hydrophilic due to the strong surface hydration compared with PDA-coated surfaces. The peptide-functionalised surfaces showed resistance to human blood serum adsorption and also effectively prevented the adhesion of gram-negative and gram-positive bacteria (i.e., Escherichia coli and Staphylococcus epidermidis) and mammalian cells (i.e., NIH 3T3 mouse embryonic fibroblast cells). The versatility of mussel-inspired chemistry combined with the unique biological nature and tunability of peptides allows for the design of low-fouling surfaces, making this a promising coating technique for various applications.

Graphical abstract: Nanoscale engineering of low-fouling surfaces through polydopamine immobilisation of zwitterionic peptides

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Publication details

The article was received on 09 Dec 2013, accepted on 04 Feb 2014 and first published on 17 Feb 2014


Article type: Paper
DOI: 10.1039/C3SM53056F
Citation: Soft Matter, 2014,10, 2656-2663
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    Nanoscale engineering of low-fouling surfaces through polydopamine immobilisation of zwitterionic peptides

    J. Cui, Y. Ju, K. Liang, H. Ejima, S. Lörcher, K. T. Gause, J. J. Richardson and F. Caruso, Soft Matter, 2014, 10, 2656
    DOI: 10.1039/C3SM53056F

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