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Issue 12, 2014
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Energy barriers and cell migration in densely packed tissues

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Abstract

Recent observations demonstrate that confluent tissues exhibit features of glassy dynamics, such as caging behavior and dynamical heterogeneities, although it has remained unclear how single-cell properties control this behavior. Here we develop numerical and theoretical models to calculate energy barriers to cell rearrangements, which help govern cell migration in cell monolayers. In contrast to work on sheared foams, we find that energy barrier heights are exponentially distributed and depend systematically on the cell's number of neighbors. Based on these results, we predict glassy two-time correlation functions for cell motion, with a timescale that increases rapidly as cell activity decreases. These correlation functions are used to construct simple random walks that reproduce the caging behavior observed for cell trajectories in experiments. This work provides a theoretical framework for predicting collective motion of cells in wound-healing, embryogenesis and cancer tumorogenesis.

Graphical abstract: Energy barriers and cell migration in densely packed tissues

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Article information


Submitted
17 Nov 2013
Accepted
06 Feb 2014
First published
06 Feb 2014

Soft Matter, 2014,10, 1885-1890
Article type
Communication

Energy barriers and cell migration in densely packed tissues

D. Bi, J. H. Lopez, J. M. Schwarz and M. L. Manning, Soft Matter, 2014, 10, 1885
DOI: 10.1039/C3SM52893F

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