Issue 7, 2014

Microarrays and single molecules: an exciting combination


Biomolecules positioned at interfaces have spawned many applications in bioanalysis, biophysics, and cell biology. This Highlight describes recent developments in the research areas of protein and DNA arrays, and single-molecule sensing. We cover the ultrasensitive scanning of conventional microarrays as well as the generation of arrays composed of individual molecules. The combination of these tools has improved the detection limits and the dynamic range of microarray analysis, helped develop powerful single-molecule sequencing approaches, and offered biophysical examination with high throughput and molecular detail. The topic of this Highlight integrates several disciplines and is written for interested chemists, biophysicists and nanotechnologists.

Graphical abstract: Microarrays and single molecules: an exciting combination

Article information

Article type
02 Oct 2013
09 Dec 2013
First published
09 Jan 2014
This article is Open Access
Creative Commons BY license

Soft Matter, 2014,10, 931-941

Microarrays and single molecules: an exciting combination

S. Howorka and J. Hesse, Soft Matter, 2014, 10, 931 DOI: 10.1039/C3SM52561A

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