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Issue 7, 2014
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Microarrays and single molecules: an exciting combination

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Abstract

Biomolecules positioned at interfaces have spawned many applications in bioanalysis, biophysics, and cell biology. This Highlight describes recent developments in the research areas of protein and DNA arrays, and single-molecule sensing. We cover the ultrasensitive scanning of conventional microarrays as well as the generation of arrays composed of individual molecules. The combination of these tools has improved the detection limits and the dynamic range of microarray analysis, helped develop powerful single-molecule sequencing approaches, and offered biophysical examination with high throughput and molecular detail. The topic of this Highlight integrates several disciplines and is written for interested chemists, biophysicists and nanotechnologists.

Graphical abstract: Microarrays and single molecules: an exciting combination

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Article information


Submitted
02 Oct 2013
Accepted
09 Dec 2013
First published
09 Jan 2014

This article is Open Access

Soft Matter, 2014,10, 931-941
Article type
Highlight

Microarrays and single molecules: an exciting combination

S. Howorka and J. Hesse, Soft Matter, 2014, 10, 931
DOI: 10.1039/C3SM52561A

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