Issue 9, 2014

Antigenically shielded universal red blood cells by polydopamine-based cell surface engineering

Abstract

Blood type mismatching is a critical problem in blood transfusions and it occasionally leads to severe transfusion reactions and even patient death. Inspired by the adhesive proteins secreted by mussels, we suggest a catecholic chemistry-based strategy to shelter antigenic epitopes on red blood cells (RBCs) by using polydopamine (PDA), which can guard against coagulation reaction without other negative effects on the RBC structure, function and viability. Both in vitro and in vivo studies confirm that the PDA-engineered RBCs (PDA-RBCs) can be applied in blood transfusion practices. The systemic assessment using a murine model demonstrates that the modified RBCs have a perfect survival profile even with repeated transfusion and high transfusion rates up to around 60%. It follows that an appropriate biogenic-chemical modification can produce antigenically shielded universal RBCs and provide insight for cell transplantation by using cell surface engineering.

Graphical abstract: Antigenically shielded universal red blood cells by polydopamine-based cell surface engineering

Supplementary files

Article information

Article type
Edge Article
Submitted
16 Apr 2014
Accepted
15 May 2014
First published
15 May 2014

Chem. Sci., 2014,5, 3463-3468

Author version available

Antigenically shielded universal red blood cells by polydopamine-based cell surface engineering

B. Wang, G. Wang, B. Zhao, J. Chen, X. Zhang and R. Tang, Chem. Sci., 2014, 5, 3463 DOI: 10.1039/C4SC01120A

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