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Issue 7, 2014
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Practical synthesis of water-soluble organic nanoparticles with a single reactive group and a functional carrier scaffold

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Abstract

A new approach to prepare functional organic nanoparticles (ONPs) from linear polymers is described. The nanoparticles are obtained by ring-opening metathesis polymerisation (ROMP) of functionalised norbornene dicarboximides, side-chain amidation with tri-O-allyl-TRIS, and ring-closing metathesis (RCM). The synthesis is quite flexible and mild, allowing preparation of organic- and aqueous-soluble particles with narrow molecular weight (MW) distributions that are tunable, ranging from MW ≈ 10 to >100 kD with diameters between ca. 5 and 50 nm. The use of functional monomer(s) and/or chain-transfer agents (CTAs) leads to the fully controlled synthesis of nanoparticles containing single or multiple reactive functional groups. This non-toxic ONP scaffold can be readily used as a protective carrier for a broad range of groups using the appropriate monomers, such as a fluorescein-functionalised monomer that affords fluorescent ONPs with significantly enhanced photostability.

Graphical abstract: Practical synthesis of water-soluble organic nanoparticles with a single reactive group and a functional carrier scaffold

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Supplementary files

Article information


Submitted
07 Mar 2014
Accepted
21 Apr 2014
First published
23 Apr 2014

Chem. Sci., 2014,5, 2862-2868
Article type
Edge Article
Author version available

Practical synthesis of water-soluble organic nanoparticles with a single reactive group and a functional carrier scaffold

Y. Bai, H. Xing, G. A. Vincil, J. Lee, E. J. Henderson, Y. Lu, N. G. Lemcoff and S. C. Zimmerman, Chem. Sci., 2014, 5, 2862
DOI: 10.1039/C4SC00700J

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