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Issue 6, 2014
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Highly sensitive and selective detection of the pyrophosphate anion biomarker under physiological conditions

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Abstract

A multidentate adsorbate having a bis(carbazolyl)urea unit, as a receptor for hydrogen pyrophosphate anions, and two cyclic bidentate alkyl disulfide groups, as linkers to gold surfaces, has been designed and synthesized. Self-assembled monolayers (SAMs) on gold of this adsorbate have been obtained and characterized showing a high robustness along with an extremely large sensitivity and selectivity for hydrogen pyrophosphate anions enabling to be used as a surface plasmon resonance (SPR) sensor for the detection of such anions at the ppt concentration level under physiological conditions.

Graphical abstract: Highly sensitive and selective detection of the pyrophosphate anion biomarker under physiological conditions

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Publication details

The article was received on 05 Nov 2013, accepted on 05 Feb 2014 and first published on 11 Feb 2014


Article type: Edge Article
DOI: 10.1039/C3SC53058B
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Citation: Chem. Sci., 2014,5, 2328-2335

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    Highly sensitive and selective detection of the pyrophosphate anion biomarker under physiological conditions

    G. Sánchez, D. Curiel, W. Tatkiewcz, I. Ratera, A. Tárraga, J. Veciana and P. Molina, Chem. Sci., 2014, 5, 2328
    DOI: 10.1039/C3SC53058B

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