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Issue 4, 2014
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Consecutive dynamic resolutions of phosphine oxides

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Abstract

A crystallization-induced asymmetric transformation (CIAT) involving a radical-mediated racemization provides access to enantiopure secondary phosphine oxides. A consecutive CIAT is used to prepare enantio- and diastereo-pure tert-butyl(hydroxyalkyl)phenylphosphine oxides.

Graphical abstract: Consecutive dynamic resolutions of phosphine oxides

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Article information


Submitted
21 Oct 2013
Accepted
26 Nov 2013
First published
27 Nov 2013

Chem. Sci., 2014,5, 1322-1327
Article type
Edge Article

Consecutive dynamic resolutions of phosphine oxides

F. A. Kortmann, M. Chang, E. Otten, E. P. A. Couzijn, M. Lutz and A. J. Minnaard, Chem. Sci., 2014, 5, 1322
DOI: 10.1039/C3SC52913D

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