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Issue 2, 2014
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Cytochrome P450-catalyzed insertion of carbenoids into N–H bonds

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Abstract

Expanding nature's catalytic repertoire to include reactions important in synthetic chemistry will open new opportunities for ‘green’ chemistry and biosynthesis. We demonstrate the first enzyme-catalyzed insertion of carbenoids into N–H bonds. This type of bond disconnection, which has no counterpart in nature, can be mediated by variants of the cytochrome P450 from Bacillus megaterium. The N–H insertion reaction takes place in water, provides the desired products in 26–83% yield, forms the single addition product exclusively, and does not require slow addition of the diazo component.

Graphical abstract: Cytochrome P450-catalyzed insertion of carbenoids into N–H bonds

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Supplementary files

Article information


Submitted
09 Sep 2013
Accepted
01 Nov 2013
First published
04 Nov 2013

Chem. Sci., 2014,5, 598-601
Article type
Edge Article

Cytochrome P450-catalyzed insertion of carbenoids into N–H bonds

Z. J. Wang, N. E. Peck, H. Renata and F. H. Arnold, Chem. Sci., 2014, 5, 598
DOI: 10.1039/C3SC52535J

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