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Issue 1, 2014
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Rh(iii)-catalyzed C–H activation–desymmetrization of diazabicycles with arenes: facile synthesis of functionalized cyclopentenes

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Abstract

A Rh(III)-catalyzed C–H activation–desymmetrization of diazabicycles with arenes as an expedient approach to functionalized cyclopentenes is reported. This protocol provides a novel and efficient strategy for the desymmetrization of diazabicycles, featuring simple starting materials, mild reaction conditions, high efficiency and broad substrate scope. Control experiments and a kinetic isotope effect study were conducted, and a plausible mechanism was proposed.

Graphical abstract: Rh(iii)-catalyzed C–H activation–desymmetrization of diazabicycles with arenes: facile synthesis of functionalized cyclopentenes

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Supplementary files

Article information


Submitted
07 Sep 2013
Accepted
27 Sep 2013
First published
27 Sep 2013

Chem. Sci., 2014,5, 297-302
Article type
Edge Article

Rh(III)-catalyzed C–H activation–desymmetrization of diazabicycles with arenes: facile synthesis of functionalized cyclopentenes

Y. Zhang, Q. Wu and S. Cui, Chem. Sci., 2014, 5, 297
DOI: 10.1039/C3SC52524D

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