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Issue 61, 2016, Issue in Progress
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Self-assembled collagen-like-peptide implants as alternatives to human donor corneal transplantation

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Abstract

Extracellular matrix proteins like collagen promote regeneration as implants in clinical studies. However, collagens are large and unwieldy proteins, making small functional peptide analogs potentially ideal substitutes. Self-assembling collagen-like-peptides conjugated with PEG-maleimide were assembled into hydrogels. When tested pre-clinically as corneal implants in mini-pigs, they promoted cell and nerve regeneration, forming neo-corneas structurally and functionally similar to natural corneas.

Graphical abstract: Self-assembled collagen-like-peptide implants as alternatives to human donor corneal transplantation

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Supplementary files

Article information


Submitted
06 Apr 2016
Accepted
30 May 2016
First published
01 Jun 2016

RSC Adv., 2016,6, 55745-55749
Article type
Communication
Author version available

Self-assembled collagen-like-peptide implants as alternatives to human donor corneal transplantation

M. M. Islam, R. Ravichandran, D. Olsen, M. K. Ljunggren, P. Fagerholm, C. J. Lee, M. Griffith and J. Phopase, RSC Adv., 2016, 6, 55745
DOI: 10.1039/C6RA08895C

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