Jump to main content
Jump to site search

Issue 61, 2016, Issue in Progress
Previous Article Next Article

Self-assembled collagen-like-peptide implants as alternatives to human donor corneal transplantation

Author affiliations

Abstract

Extracellular matrix proteins like collagen promote regeneration as implants in clinical studies. However, collagens are large and unwieldy proteins, making small functional peptide analogs potentially ideal substitutes. Self-assembling collagen-like-peptides conjugated with PEG-maleimide were assembled into hydrogels. When tested pre-clinically as corneal implants in mini-pigs, they promoted cell and nerve regeneration, forming neo-corneas structurally and functionally similar to natural corneas.

Graphical abstract: Self-assembled collagen-like-peptide implants as alternatives to human donor corneal transplantation

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Apr 2016, accepted on 30 May 2016 and first published on 01 Jun 2016


Article type: Communication
DOI: 10.1039/C6RA08895C
Author version
available:
Download author version (PDF)
Citation: RSC Adv., 2016,6, 55745-55749
  •   Request permissions

    Self-assembled collagen-like-peptide implants as alternatives to human donor corneal transplantation

    M. M. Islam, R. Ravichandran, D. Olsen, M. K. Ljunggren, P. Fagerholm, C. J. Lee, M. Griffith and J. Phopase, RSC Adv., 2016, 6, 55745
    DOI: 10.1039/C6RA08895C

Search articles by author

Spotlight

Advertisements