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Issue 102, 2015
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Electrostatic template-assisted deposition of microparticles on electrospun nanofibers: towards microstructured functional biochips for screening applications

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Abstract

Electrostatic Template-Assisted Deposition (ETAD) of microparticles is described as a new process to control the deposition of microparticles by electrospraying onto a substrate. It relies on the construction of an electrostatic template by electrospinning a thin layer of fibers onto a micropatterned collector. Because the fibers cannot release their charges when they are suspended over cavities of the micropatterned collector, an electrostatic template is formed with repulsive and attractive domains. This electrostatic template is then used to guide precisely the particle deposition during the electrospraying step. Microstructured bi-layer composites with a great variety of micropatterns can thus be elaborated with any kind of materials allowing the use of the ETAD process for a wide range of applications. As a proof of concept, the ETAD process was applied for the production of composite scaffolds with poly(ε-caprolactone) nanofibers covered by a micropatterned layer of hydroxyapatite. This scaffold was then embedded in a biochip containing 21 wells and used for MG-63 cell proliferation and mineralization studies, showing their possible application in the screening of the scaffold structure for tissue engineering.

Graphical abstract: Electrostatic template-assisted deposition of microparticles on electrospun nanofibers: towards microstructured functional biochips for screening applications

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Supplementary files

Article information


Submitted
08 Aug 2015
Accepted
28 Sep 2015
First published
28 Sep 2015

This article is Open Access

RSC Adv., 2015,5, 83600-83607
Article type
Paper
Author version available

Electrostatic template-assisted deposition of microparticles on electrospun nanofibers: towards microstructured functional biochips for screening applications

S. Nedjari, A. Hébraud, S. Eap, S. Siegwald, C. Mélart, N. Benkirane-Jessel and G. Schlatter, RSC Adv., 2015, 5, 83600
DOI: 10.1039/C5RA15931H

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