Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 105, 2014
Previous Article Next Article

Recent advances in the synthesis, characterization, and biomedical applications of ultrasmall thiolated silver nanoclusters

Author affiliations

Abstract

With ultrasmall particle sizes of ∼1 nm, thiolate-protected silver nanoclusters (or thiolated Ag NCs) have recently emerged as an attractive frontier of nanoparticle research because of their unique molecular-like properties, such as well-defined molecular structures, HOMO–LUMO transitions, quantized charging, and strong luminescence. Such intriguing physicochemical properties have made thiolated Ag NCs a new class of promising theranostic agents for a wide spectrum of biomedical applications, such as bioimaging, antimicrobial agents, and disease diagnostics and therapy. In turn, the promising applications of thiolated Ag NCs have also fuelled the cluster community to develop more efficient strategies to synthesize high-quality Ag NCs with well-defined size, structure, and surface. In this review article, we first survey recent advances in developing efficient synthetic strategies for thiolated Ag NCs, highlighting the underlying chemistry that makes the delicate control of their sizes and surfaces possible. In the second section, we discuss recent advances in characterization techniques for ultrasmall thiolated Ag NCs, including their physical, chemical, and biological properties. The emerging characterization techniques are central to the development of cluster chemistry. In the last section, we highlight some examples demonstrating the vast possibilities of thiolated Ag NCs for biomedical applications. We conclude this review article by pointing out some challenging issues related to thiolated Ag NCs, and hopefully these can encourage more concerted efforts on their study from the research communities of cluster chemistry, noble metal chemistry, biology, biomedicine, etc.

Graphical abstract: Recent advances in the synthesis, characterization, and biomedical applications of ultrasmall thiolated silver nanoclusters

Back to tab navigation

Article information


Submitted
09 Oct 2014
Accepted
28 Oct 2014
First published
29 Oct 2014

RSC Adv., 2014,4, 60581-60596
Article type
Review Article

Recent advances in the synthesis, characterization, and biomedical applications of ultrasmall thiolated silver nanoclusters

K. Zheng, X. Yuan, N. Goswami, Q. Zhang and J. Xie, RSC Adv., 2014, 4, 60581
DOI: 10.1039/C4RA12054J

Social activity

Search articles by author

Spotlight

Advertisements