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Issue 102, 2014
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A novel curcumin–artemisinin coamorphous solid: physical properties and pharmacokinetic profile

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Abstract

Here we report a curcumin–artemisinin coamorphous solid (1 : 1) prepared by rotavaporization and a dramatic increase in the pharmacokinetic profile of curcumin (AUC0–12 2.6 μg h mL−1, Cmax 1 μg mL−1) administered as CUR–ART to SD rats. PXRD and FESEM analysis explains the molecular basis for the solubility enhancement of coamorphous CUR–ART.

Graphical abstract: A novel curcumin–artemisinin coamorphous solid: physical properties and pharmacokinetic profile

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Publication details

The article was received on 07 Oct 2014, accepted on 28 Oct 2014 and first published on 29 Oct 2014


Article type: Communication
DOI: 10.1039/C4RA11935E
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Citation: RSC Adv., 2014,4, 58357-58361
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    A novel curcumin–artemisinin coamorphous solid: physical properties and pharmacokinetic profile

    K. Suresh, M. K. C. Mannava and A. Nangia, RSC Adv., 2014, 4, 58357
    DOI: 10.1039/C4RA11935E

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