Issue 103, 2014
From the journal:

RSC Advances

Delineating Monascus azaphilone pigment biosynthesis: oxidoreductive modifications determine the ring cyclization pattern in azaphilone biosynthesis†

Balakrishnan Bijinu,a   Jae-Won Suh,a   Si-Hyung Parkb  and  Hyung-Jin Kwon*a  

* Corresponding authors

a Department of Biological Science, Myongji University, Yongin 449-728, Republic of Korea
E-mail: hjink@mju.ac.kr

b Department of Oriental Medicine Resources, Mokpo National University, Muan 534-729, Republic of Korea

Abstract

The product profiles of mppF, mppA, and mppC mutants substantiate that MppA-mediated ω-2 ketoreduction is a prerequisite for the synthesis of the pyranoquinone bicyclic core of the Monascus azaphilone pigment and that MppC activity determines the regioselectivity of the spontaneous Knoevenagel condensation.

Graphical abstract: Delineating Monascus azaphilone pigment biosynthesis: oxidoreductive modifications determine the ring cyclization pattern in azaphilone biosynthesis

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Article information

DOI
https://doi.org/10.1039/C4RA11713A
Article type
Communication
Submitted
03 Oct 2014
Accepted
31 Oct 2014
First published
03 Nov 2014

RSC Adv., 2014,4, 59405-59408

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Delineating Monascus azaphilone pigment biosynthesis: oxidoreductive modifications determine the ring cyclization pattern in azaphilone biosynthesis

B. Bijinu, J. Suh, S. Park and H. Kwon, RSC Adv., 2014, 4, 59405 DOI: 10.1039/C4RA11713A

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