NH4PF6-promoted cyclodehydration of α-amino carbonyl compounds: efficient synthesis of pyrrolo[3,2,1-ij]quinoline and indole derivatives

Abstract

NH₄PF₆ is an inexpensive, safe, and low-toxicity inorganic salt; it was found to promote the cyclodehydration of α-amino carbonyl compounds in the absence of metal reagents. This simple cyclodehydration strategy enables highly atom-economic formation of pyrrolo[3,2,1-ij]quinoline and indole derivatives, which are significant pharmacophores.