Issue 109, 2014
From the journal:

RSC Advances

Effect of magnetic modulation of mitochondrial voltage-dependent anion channel 2 against beta-amyloid induced neurotoxicity†

Sujin Lee,a   Junghoon Lee,a   Sang Jun Simb  and  Misun Cha*b  

* Corresponding authors

a School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, South Korea

b Department of Chemical Engineering and Biological Engineering, Korea University, Seoul, South Korea
E-mail: cmsbestok@gmail.com
Fax: +82-2-926-6102
Tel: +82-2-3290-3686

Abstract

The magnetic capture of mitochondrial VDAC2 with bacterial magnetic particles (BMPs) conjugated VDAC2 antibody (BMPs–Ab) significantly decreased the expressed intracellular calcium levels and neurotoxicity induced by Aβ. This magnetic modulation of mitochondrial VDAC, playing a key role in various Ca2+ flux pathways, should provide attractive targets for the future development of AD treatments.

Graphical abstract: Effect of magnetic modulation of mitochondrial voltage-dependent anion channel 2 against beta-amyloid induced neurotoxicity

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Article information

DOI
https://doi.org/10.1039/C4RA10755A
Article type
Communication
Submitted
19 Sep 2014
Accepted
05 Nov 2014
First published
06 Nov 2014

RSC Adv., 2014,4, 63681-63684

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Effect of magnetic modulation of mitochondrial voltage-dependent anion channel 2 against beta-amyloid induced neurotoxicity

S. Lee, J. Lee, S. J. Sim and M. Cha, RSC Adv., 2014, 4, 63681 DOI: 10.1039/C4RA10755A

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