A convenient acid-promoted cyclization protocol for the formation of azaheterocycles from amino alcohols is described. The reaction involves the use of N,N-dimethylacetamide dimethyl acetal (DMADA) as the activating reagent of the hydroxyl group. Using this protocol, pyrrolidines or piperidines with various substituents can be synthesized in good to high yields.
S. Hwang, H. Park, Y. Kwon and S. Kim, RSC Adv., 2014, 4, 60017 DOI: 10.1039/C4RA10625C
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