Regioselective one-pot, three-component synthesis of substituted 2H-indazoles from 2-nitroarylaldehyde, alkyne and amine catalyzed by the CuBr/Zn(OTf)2 system

Anil K. Saikia; Ramanjaneyulu Unnava; Kiran Indukuri; Sujit Sarkar

doi:10.1039/C4RA10093J

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Regioselective one-pot, three-component synthesis of substituted 2H-indazoles from 2-nitroarylaldehyde, alkyne and amine catalyzed by the CuBr/Zn(OTf)₂ system†

Anil K. Saikia,*^a Ramanjaneyulu Unnava,^a Kiran Indukuri^a and Sujit Sarkar^a

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^a Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, India
E-mail: asaikia@iitg.ernet.in
Fax: +91-361-2690762
Tel: +91-361-2582316

Abstract

3-(Arylethynyl)-2H-indazoles can be effectively synthesized in one-pot using 2-nitroarylaldehydes, primary amines and alkynes co-catalyzed by copper(I) bromide and zinc(II) triflate. This method has a broad substrate scope with high to medium tolerance for a variety of functional groups.

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Article information

DOI: https://doi.org/10.1039/C4RA10093J
Article type: Communication
Submitted: 09 Sep 2014
Accepted: 22 Oct 2014
First published: 23 Oct 2014

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RSC Adv., 2014,4, 55296-55299

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Regioselective one-pot, three-component synthesis of substituted 2H-indazoles from 2-nitroarylaldehyde, alkyne and amine catalyzed by the CuBr/Zn(OTf)₂ system

A. K. Saikia, R. Unnava, K. Indukuri and S. Sarkar, RSC Adv., 2014, 4, 55296 DOI: 10.1039/C4RA10093J

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