Issue 100, 2014

One-pot synthesis and evaluation of novel 3-aryl-6-ethoxycarbonyl-4-hydroxy-2H-pyran-2-one as a potent cytotoxic agent

Abstract

A series of new open chain analogs of Phelligridin J were synthesized by a clean one-pot approach. These compounds were evaluated for their in vitro cytotoxicity against normal and breast cancer cell lines. All the compounds exhibited potent cytotoxic activity in the lower micro molar range. Compound 5o exhibited the maximum cytotoxic activity with IC50 values of 12.49 and 13.76 μM, whereas compound 5a showed two-fold selectivity viz. IC50 values of 21.80 to 43.40 μM against breast cancer (MCF7) and normal fibroblast (NIH3T3) cell lines, respectively.

Graphical abstract: One-pot synthesis and evaluation of novel 3-aryl-6-ethoxycarbonyl-4-hydroxy-2H-pyran-2-one as a potent cytotoxic agent

Supplementary files

Article information

Article type
Paper
Submitted
08 Sep 2014
Accepted
14 Oct 2014
First published
17 Oct 2014

RSC Adv., 2014,4, 56870-56875

Author version available

One-pot synthesis and evaluation of novel 3-aryl-6-ethoxycarbonyl-4-hydroxy-2H-pyran-2-one as a potent cytotoxic agent

G. R. Dhage, S. R. Thopate, S. N. Ramteke and P. P. Kulkarni, RSC Adv., 2014, 4, 56870 DOI: 10.1039/C4RA10015H

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