Direct arylation of heterocycles through C–H bond cleavage using metal–organic-framework Cu2(OBA)2(BPY) as an efficient heterogeneous catalyst

Abstract

A crystalline porous metal–organic-framework Cu₂(OBA)₂(BPY) was synthesized and characterized by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), Fourier transform infrared (FT-IR), atomic absorption spectrophotometry (AAS), and nitrogen physisorption measurements. The Cu-MOF was shown to be an efficient heterogeneous catalyst for direct C-arylation of a variety of heterocycles by iodoarenes. The optimal conditions employed tBuOLi in dioxane at elevated temperature. In addition, a leaching test was also conducted to investigate the heterogeneity. Gratifyingly, the MOF catalyst can be facilely recycled several times under identical conditions without remarkable loss in catalytic reactivity.