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Issue 96, 2014

Easy preparation of an MRI contrast agent with high longitudinal relaxivity based on gadolinium ions-loaded graphene oxide

Author affiliations

Abstract

As far as the longitudinal relaxivity (r1) is concerned, gadolinium ions (Gd3+)-based MRI contrast agents modified by traditional carriers do not appear to be far superior to the clinically used Magnevist. In this study, a type of MRI contrast agent (Gd3+@CGO) possessing a significantly high r1 value was easily prepared using a carboxyl-functionalized graphene oxide (CGO) as a nanocarrier to directly interact with GdCl3·6H2O. With 2.8 wt% of Gd3+ loaded on CGO, the prepared Gd3+@CGO shows good dispersibility in water and possesses r1 of 63.8 mM−1 S−1, which is 14 times higher than that of Magnevist. It is exciting to note that Gd3+ anchored on CGO remains stable at least for one year, probably relying on the electrostatic adsorption and physical encapsulation effect of CGO towards Gd3+.

Graphical abstract: Easy preparation of an MRI contrast agent with high longitudinal relaxivity based on gadolinium ions-loaded graphene oxide

Supplementary files

Article information


Submitted
22 Aug 2014
Accepted
01 Oct 2014
First published
01 Oct 2014

RSC Adv., 2014,4, 53987-53992
Article type
Paper
Author version available

Easy preparation of an MRI contrast agent with high longitudinal relaxivity based on gadolinium ions-loaded graphene oxide

X. Ren, X. Jing, L. Liu, L. Guo, M. Zhang and Y. Li, RSC Adv., 2014, 4, 53987 DOI: 10.1039/C4RA09073J

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