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Issue 93, 2014
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Meglumine catalyzed expeditious four-component domino protocol for synthesis of pyrazolopyranopyrimidines in aqueous medium

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Abstract

A facile and highly efficient protocol for the one-pot, four-component reaction of ethyl acetoacetate, hydrazine hydrate, aromatic aldehydes and barbituric acid has been developed using meglumine as an inexpensive, biodegradable and reusable catalyst. This methodology provides a mild and fast route to structurally diverse tricyclic fused pyrazolopyranopyrimidines in good to excellent yields. Simplicity, room temperature reaction conditions, a green solvent, an easy work-up process, inexpensive price and reusability of the catalyst are the main advantages of this method.

Graphical abstract: Meglumine catalyzed expeditious four-component domino protocol for synthesis of pyrazolopyranopyrimidines in aqueous medium

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Article information


Submitted
15 Aug 2014
Accepted
02 Oct 2014
First published
03 Oct 2014

RSC Adv., 2014,4, 51580-51588
Article type
Paper
Author version available

Meglumine catalyzed expeditious four-component domino protocol for synthesis of pyrazolopyranopyrimidines in aqueous medium

X. Li, A. Zhao, L. Mo and Z. Zhang, RSC Adv., 2014, 4, 51580
DOI: 10.1039/C4RA08689A

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