Issue 93, 2014

Meglumine catalyzed expeditious four-component domino protocol for synthesis of pyrazolopyranopyrimidines in aqueous medium

Abstract

A facile and highly efficient protocol for the one-pot, four-component reaction of ethyl acetoacetate, hydrazine hydrate, aromatic aldehydes and barbituric acid has been developed using meglumine as an inexpensive, biodegradable and reusable catalyst. This methodology provides a mild and fast route to structurally diverse tricyclic fused pyrazolopyranopyrimidines in good to excellent yields. Simplicity, room temperature reaction conditions, a green solvent, an easy work-up process, inexpensive price and reusability of the catalyst are the main advantages of this method.

Graphical abstract: Meglumine catalyzed expeditious four-component domino protocol for synthesis of pyrazolopyranopyrimidines in aqueous medium

Article information

Article type
Paper
Submitted
15 Aug 2014
Accepted
02 Oct 2014
First published
03 Oct 2014

RSC Adv., 2014,4, 51580-51588

Author version available

Meglumine catalyzed expeditious four-component domino protocol for synthesis of pyrazolopyranopyrimidines in aqueous medium

X. Li, A. Zhao, L. Mo and Z. Zhang, RSC Adv., 2014, 4, 51580 DOI: 10.1039/C4RA08689A

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