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Issue 75, 2014
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Self-assembled insect muscle bioactuators with long term function under a range of environmental conditions

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Abstract

The use of mammalian muscles as device actuators is severely limited by their sensitivity to environmental conditions and short lifetime. To overcome these limitations insect muscle stem cells were used to generate organized 3D muscle constructs with significant enhancements in environmental tolerance and long term function. These tissues self-assembled, self-repaired, survived for months in culture without media replenishment and produced stresses of up to 2 kPa, all under ambient conditions. The muscle tissues continued to function for days even under biologically extreme temperature and pH. Furthermore, the dimensions and geometry of these tissues can be easily scaled to MEMS or meso-scale devices. The versatility, environmental hardiness and long term function provide a new path forward for biological actuators for device needs.

Graphical abstract: Self-assembled insect muscle bioactuators with long term function under a range of environmental conditions

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Publication details

The article was received on 17 Jul 2014, accepted on 15 Aug 2014 and first published on 15 Aug 2014


Article type: Paper
DOI: 10.1039/C4RA08438A
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RSC Adv., 2014,4, 39962-39968

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    Self-assembled insect muscle bioactuators with long term function under a range of environmental conditions

    A. L. Baryshyan, L. J. Domigan, B. Hunt, B. A. Trimmer and D. L. Kaplan, RSC Adv., 2014, 4, 39962
    DOI: 10.1039/C4RA08438A

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