Pegaharmalines A and B, two novel β-carboline alkaloids with unprecedented carbon skeletons from Peganum harmala

Kai-Bo Wang; Chun-Mao Yuan; Chun-Mei Xue; Da-Hong Li; Yong-Kui Jing; Hong-Ping He; Xiao-Jiang Hao; Ying-Tong Di; Zhan-Lin Li; Hui-Ming Hua

doi:10.1039/C4RA07985J

Pegaharmalines A and B, two novel β-carboline alkaloids with unprecedented carbon skeletons from Peganum harmala†

Kai-Bo Wang,^a Chun-Mao Yuan,^b Chun-Mei Xue,^a Da-Hong Li,^a Yong-Kui Jing,^c Hong-Ping He,^b Xiao-Jiang Hao,^b Ying-Tong Di,*^b Zhan-Lin Li*^a and Hui-Ming Hua*^a

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* Corresponding authors

^a Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China
E-mail: huimhua@163.com, lzl1030@hotmail.com
Tel: +86-24-23986465/+86-24-23986488

^b State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China
E-mail: diyt@mail.kib.ac.cn

^c Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA

Abstract

Pegaharmalines A (1) and B (2), two novel β-carboline alkaloids with unprecedented carbon skeletons, were isolated from the seeds of Peganum harmala. Their structures were determined by spectroscopic methods and the absolute configuration of 1 was elucidated by CD analysis. 1 and 2 exhibited significant cytotoxicities on HL-60 cells with IC₅₀ values of 9.4 and 13.6 μM, respectively.

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Pegaharmalines A and B, two novel β-carboline alkaloids with unprecedented carbon skeletons from Peganum harmala†

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Pegaharmalines A and B, two novel β-carboline alkaloids with unprecedented carbon skeletons from Peganum harmala

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