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Issue 86, 2014
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Mesoporous silica-coated luminescent Eu3+ doped GdVO4 nanoparticles for multimodal imaging and drug delivery

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Abstract

We describe a simple method for synthesizing mesoporous silica-coated luminescent europium-doped gadolinium vanadate (GdVO4:Eu3+@mSiO2) nanoparticles. Their biomedical applications as a potential imaging nanoprobe for both fluorescence imaging and magnetic resonance imaging (MRI) and as a simultaneous anti-cancer drug delivery vehicle are also discussed. Eu3+ doped GdVO4 nanoparticles exhibit strong red photoluminescence and the Gd3+ in GdVO4 can be used as a T1 contrast agent for MRI. T1-weighted MR contrast enhancement as well as sustained intracellular drug delivery can be achieved by the mesoporous silica layer coating onto a single nanoparticle. Enhanced T1 MR contrast was proven by relaxometric studies on water access to the paramagnetic core. GdVO4:Eu3+@mSiO2 nanoparticles as a new type of theragnostic (imaging and treatment) agent can provide new opportunities in a cancer treatment.

Graphical abstract: Mesoporous silica-coated luminescent Eu3+ doped GdVO4 nanoparticles for multimodal imaging and drug delivery

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Publication details

The article was received on 04 Jul 2014, accepted on 12 Sep 2014 and first published on 12 Sep 2014


Article type: Paper
DOI: 10.1039/C4RA06628F
RSC Adv., 2014,4, 45687-45695

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    Mesoporous silica-coated luminescent Eu3+ doped GdVO4 nanoparticles for multimodal imaging and drug delivery

    T. Kim, N. Lee, Y. I. Park, J. Kim, J. Kim, E. Y. Lee, M. Yi, B. Kim, T. Hyeon, T. Yu and H. B. Na, RSC Adv., 2014, 4, 45687
    DOI: 10.1039/C4RA06628F

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