Issue 60, 2014

Azide trapping of metallocarbenes: generation of reactive C-acylimines and domino trapping with nucleophiles

Abstract

Azide-tethered diazocarbonyl compounds undergo copper-catalyzed conversion to transient C-acylimines. These reactive intermediates can be trapped with a variety of carbon nucleophiles, giving rise to complex 3-indolinone frameworks, including those with adjacent tetra-substituted carbon centers, in a single transformation.

Graphical abstract: Azide trapping of metallocarbenes: generation of reactive C-acylimines and domino trapping with nucleophiles

Supplementary files

Article information

Article type
Communication
Submitted
16 May 2014
Accepted
09 Jul 2014
First published
10 Jul 2014

RSC Adv., 2014,4, 31955-31959

Author version available

Azide trapping of metallocarbenes: generation of reactive C-acylimines and domino trapping with nucleophiles

T. M. Bott, B. J. Atienza and F. G. West, RSC Adv., 2014, 4, 31955 DOI: 10.1039/C4RA06044J

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