A new and one-pot version of the Gabriel phthalimide amine synthesis utilizing carbonyl compounds as alkylating agents via their tosylhydrazone surrogates is disclosed. The alkylation involves copper catalysed carbene insertion into the N–H bond of phthalimide. Basically, the protocol also offers a powerful tool for deoxygenative hydroamination of carbonyl compounds.
A. K. Yadav and L. D. S. Yadav, RSC Adv., 2014, 4, 34764 DOI: 10.1039/C4RA05929H
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