Issue 64, 2014

Preparation and in vitro release of buccal tablets of naringenin-loaded MPEG-PCL nanoparticles

Abstract

Naringenin-loaded monomethoxy poly(ethylene glycol)-poly (ε-caprolactone) (MPEG-PCL) nanoparticles (NARNP) and their formulation into buccal tablets using mucoadhesive polymers were developed to improve the solubility of naringenin and to treat oral inflammatory and ulcerative diseases. In our work, physicochemical characterizations of NARNP including particle size, zeta potential, transmission electron microscopy (TEM), differential scanning calorimetery, Fourier transform infrared spectroscopy and in vitro release were studied. NARNP buccal tablets and control buccal tablets containing MPEG-PCL copolymers and mannitol respectively were prepared and they were evaluated by weight variation, hardness, friability and in vitro release. NARNP had a small size (<100 nm), good encapsulation efficiency (95.26 ± 1.15%), and high drug loading (9.95 ± 0.15%). The lyophilized powder of NARNP showed good stability and re-solubility. For the in vitro release study of buccal tablets, Drug dissolution rate was investigated by the USP I method. To simulate in vivo conditions of the oral cavity, a new dissolution test apparatus was designed for assessment of drug release. Compared to control groups, buccal tablets containing NARNP showed more rapid and complete drug release (more than 80%) over 12 h using two dissolution test apparatuses. NARNP incorporated into buccal tablets effectively improved the release of naringenin. With desirable drug release and release time (12 h), NARNP buccal tablets may be an efficient vehicle for treatment of oral inflammatory and ulcerative diseases.

Graphical abstract: Preparation and in vitro release of buccal tablets of naringenin-loaded MPEG-PCL nanoparticles

Article information

Article type
Paper
Submitted
24 May 2014
Accepted
28 Jul 2014
First published
28 Jul 2014

RSC Adv., 2014,4, 33672-33679

Preparation and in vitro release of buccal tablets of naringenin-loaded MPEG-PCL nanoparticles

K. Wang, T. Liu, R. Lin, B. Liu, G. Yang, X. Bu, W. Wang, P. Zhang, L. Zhou and J. Zhang, RSC Adv., 2014, 4, 33672 DOI: 10.1039/C4RA04920A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements