Issue 53, 2014
From the journal:

RSC Advances

Trienediynes on a 1,3,5-trisubstituted benzene template: a new approach for enhancement of reactivity†

Ishita Hatial,a   Saibal Jana,a   Shrabani Bisai,a   Manasmita Das,b   Ananta Kumar Ghosh,c   Anakuthil Anoop*a  and  Amit Basak*a  

* Corresponding authors

a Indian Institute of Technology Kharagpur, Chemistry, Kharagpur, India
E-mail: absk@chem.iitkgp.ernet.in

b University of North Carolina, Chapel Hill, Neurology, US

c Indian Institute of Technology Kharagpur, Biotechnology, Kharagpur, India

Abstract

The synthesis of trienediynes based on a 1,3,5-trisubstituted benzene template is described. The presence of three adjacent enediyne moieties in the dendritic core exerted a cooperative effect to bring down the onset temperature for Bergman cyclization leading to increased DNA cleavage in a shorter time.

Graphical abstract: Trienediynes on a 1,3,5-trisubstituted benzene template: a new approach for enhancement of reactivity

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Article information

DOI
https://doi.org/10.1039/C4RA04794J
Article type
Communication
Submitted
21 May 2014
Accepted
13 Jun 2014
First published
13 Jun 2014

RSC Adv., 2014,4, 28041-28045

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Trienediynes on a 1,3,5-trisubstituted benzene template: a new approach for enhancement of reactivity

I. Hatial, S. Jana, S. Bisai, M. Das, A. K. Ghosh, A. Anoop and A. Basak, RSC Adv., 2014, 4, 28041 DOI: 10.1039/C4RA04794J

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