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Issue 53, 2014
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Trienediynes on a 1,3,5-trisubstituted benzene template: a new approach for enhancement of reactivity

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Abstract

The synthesis of trienediynes based on a 1,3,5-trisubstituted benzene template is described. The presence of three adjacent enediyne moieties in the dendritic core exerted a cooperative effect to bring down the onset temperature for Bergman cyclization leading to increased DNA cleavage in a shorter time.

Graphical abstract: Trienediynes on a 1,3,5-trisubstituted benzene template: a new approach for enhancement of reactivity

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Article information


Submitted
21 May 2014
Accepted
13 Jun 2014
First published
13 Jun 2014

RSC Adv., 2014,4, 28041-28045
Article type
Communication

Trienediynes on a 1,3,5-trisubstituted benzene template: a new approach for enhancement of reactivity

I. Hatial, S. Jana, S. Bisai, M. Das, A. K. Ghosh, A. Anoop and A. Basak, RSC Adv., 2014, 4, 28041
DOI: 10.1039/C4RA04794J

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