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Issue 67, 2014
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Fabrication and characterization of PNA–DNA hybrid nanostructures

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Although the distinct properties and synthesis methodology of peptide nucleic acid (PNA) molecules have been established by extensive studies, the construction of an artificial nanostructure made from PNA has been examined in only a few reports. Here we study the feasibility of constructing PNA–DNA hybrid nanostructures by conventional free solution annealing and substrate assisted growth methods. For conventional free solution annealing, we introduced a 2-step annealing procedure to mitigate the self-aggregation of PNA in the formation of stable PNA–DNA hybrid structures. Atomic force microscopy images revealed the formation of PNA–DNA hybrid nanostructures smaller than normal DNA and the Raman band intensities of the hybrid gradually decreased as a few DNA strands were replaced by PNA possibly due to the fast binding properties of PNA and the structural stress between PNA and DNA.

Graphical abstract: Fabrication and characterization of PNA–DNA hybrid nanostructures

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Article information

20 May 2014
31 Jul 2014
First published
31 Jul 2014

RSC Adv., 2014,4, 35554-35558
Article type
Author version available

Fabrication and characterization of PNA–DNA hybrid nanostructures

B. Gnapareddy, J. A. Kim, S. R. Dugasani, A. Tandon, B. Kim, S. Bashar, J. A. Choi, G. H. Joe, T. Kim, T. H. Ha and S. H. Park, RSC Adv., 2014, 4, 35554
DOI: 10.1039/C4RA04751F

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