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Issue 62, 2014
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One-pot route to β-adrenergic blockers via enantioselective organocatalysed epoxidation of terminal alkenes as a key step

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Abstract

A convenient and environmentally attractive one-pot two-step process for the synthesis of β-adrenergic blockers via Shi's organocatalytic epoxidation of terminal alkenes and subsequent aminolysis reaction of epoxides with isopropylamine under mild reaction conditions has been developed.

Graphical abstract: One-pot route to β-adrenergic blockers via enantioselective organocatalysed epoxidation of terminal alkenes as a key step

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Publication details

The article was received on 01 May 2014, accepted on 10 Jul 2014 and first published on 16 Jul 2014


Article type: Paper
DOI: 10.1039/C4RA04011B
RSC Adv., 2014,4, 32796-32801
  • Open access: Creative Commons BY license
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    One-pot route to β-adrenergic blockers via enantioselective organocatalysed epoxidation of terminal alkenes as a key step

    F. E. Held, S. Wei, K. Eder and S. B. Tsogoeva, RSC Adv., 2014, 4, 32796
    DOI: 10.1039/C4RA04011B

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