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Issue 62, 2014

One-pot route to β-adrenergic blockers via enantioselective organocatalysed epoxidation of terminal alkenes as a key step

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Abstract

A convenient and environmentally attractive one-pot two-step process for the synthesis of β-adrenergic blockers via Shi's organocatalytic epoxidation of terminal alkenes and subsequent aminolysis reaction of epoxides with isopropylamine under mild reaction conditions has been developed.

Graphical abstract: One-pot route to β-adrenergic blockers via enantioselective organocatalysed epoxidation of terminal alkenes as a key step

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Article information


Submitted
01 May 2014
Accepted
10 Jul 2014
First published
16 Jul 2014

This article is Open Access

RSC Adv., 2014,4, 32796-32801
Article type
Paper

One-pot route to β-adrenergic blockers via enantioselective organocatalysed epoxidation of terminal alkenes as a key step

F. E. Held, S. Wei, K. Eder and S. B. Tsogoeva, RSC Adv., 2014, 4, 32796 DOI: 10.1039/C4RA04011B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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