K-bis(2-ethylhexyl) phosphate (BEHPK): a novel additive for C–H arylation†
Abstract
A Ru-mediated highly efficient direct C–H arylation of α-heteroaromatic benzenes has been accomplished by addition of readily accessible K-bis(2-ethylhexyl) phosphate (BEHPK), which allowed facile and economical access to a wide range of functionalized biaryls including active pharmaceutical ingredients.