Issue 50, 2014

Manganese(ii) chloride catalyzed highly efficient one-pot synthesis of propargylamines and fused triazoles via three-component coupling reaction under solvent-free condition

Abstract

A one-pot green and highly efficient method for the synthesis of propargylamines and diastereoselective synthesis of fused triazoles via three-component coupling in the presence of manganese(II) chloride as a catalyst and a catalyst-free 1,3-dipolar cycloaddition reaction, respectively, without using a co-catalyst or activator is reported. This methodology is efficient, eco-friendly, operationally simple and effective for reactions involving aromatic, aliphatic, and heterocyclic aldehydes, and provides an easy access to propargylamines in excellent yields, fused triazoles in good yield and excellent diastereoselectivities.

Graphical abstract: Manganese(ii) chloride catalyzed highly efficient one-pot synthesis of propargylamines and fused triazoles via three-component coupling reaction under solvent-free condition

Supplementary files

Article information

Article type
Paper
Submitted
10 Apr 2014
Accepted
23 May 2014
First published
23 May 2014

RSC Adv., 2014,4, 26301-26308

Author version available

Manganese(II) chloride catalyzed highly efficient one-pot synthesis of propargylamines and fused triazoles via three-component coupling reaction under solvent-free condition

S. N. Afraj, C. Chen and G. Lee, RSC Adv., 2014, 4, 26301 DOI: 10.1039/C4RA03232B

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