Two tricyclic guanidine model compounds 28 and 29 have been prepared in 12 steps from 1,5-pentanediol using a biomimetic synthetic approach. The pivotal reaction in the sequence is a tethered Biginelli condensation between 21/22 and β-keto esters 23 and 24.
Daniel. M. Evans, P. N. Horton, M. B. Hursthouse and Patrick. J. Murphy, RSC Adv., 2014, 4, 20744 DOI: 10.1039/C4RA03031A
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