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Issue 62, 2014
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Solid-phase peptide synthesis: an overview focused on the preparation of biologically relevant peptides

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Abstract

This review article highlights the strategies to successfully perform an efficient solid-phase synthesis of complex peptides including posttranslational modifications, fluorescent labels, and reporters or linking groups of exceptional value for biological studies of several important diseases. The solid-phase approach is the best alternative to synthesize these peptides rapidly and in high amounts. The key aspects that need to be considered when performing a peptide synthesis in solid phase of these molecules are discussed.

Graphical abstract: Solid-phase peptide synthesis: an overview focused on the preparation of biologically relevant peptides

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Article information


Submitted
20 Mar 2014
Accepted
18 Jul 2014
First published
18 Jul 2014

RSC Adv., 2014,4, 32658-32672
Article type
Review Article
Author version available

Solid-phase peptide synthesis: an overview focused on the preparation of biologically relevant peptides

J. M. Palomo, RSC Adv., 2014, 4, 32658
DOI: 10.1039/C4RA02458C

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