Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 26, 2014
Previous Article Next Article

Flash carboxylation: fast lithiation–carboxylation sequence at room temperature in continuous flow

Author affiliations

Abstract

A method for the direct lithiation of terminal alkynes and heterocycles with subsequent carboxylation in a continuous flow format was developed. This method provides carboxylic acids at ambient conditions within less than five seconds with only little excess of the organometallic base and CO2.

Graphical abstract: Flash carboxylation: fast lithiation–carboxylation sequence at room temperature in continuous flow

Back to tab navigation

Supplementary files

Article information


Submitted
19 Feb 2014
Accepted
28 Feb 2014
First published
03 Mar 2014

RSC Adv., 2014,4, 13430-13433
Article type
Communication

Flash carboxylation: fast lithiation–carboxylation sequence at room temperature in continuous flow

B. Pieber, T. Glasnov and C. O. Kappe, RSC Adv., 2014, 4, 13430
DOI: 10.1039/C4RA01442A

Social activity

Search articles by author

Spotlight

Advertisements