A method for the direct lithiation of terminal alkynes and heterocycles with subsequent carboxylation in a continuous flow format was developed. This method provides carboxylic acids at ambient conditions within less than five seconds with only little excess of the organometallic base and CO2.
B. Pieber, T. Glasnov and C. O. Kappe, RSC Adv., 2014, 4, 13430 DOI: 10.1039/C4RA01442A
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