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Issue 30, 2014
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A new route to dithia- and thiaoxacyclooctynes via Nicholas reaction

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Abstract

The current paper describes a new synthesis of heteroatom-substituted cyclooctynes. By using the Nicholas reaction we managed to design a concise synthesis that only uses three steps to build the eight-membered ring. It was also possible to functionalize said alkyne with a fluorophore.

Graphical abstract: A new route to dithia- and thiaoxacyclooctynes via Nicholas reaction

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Publication details

The article was received on 15 Feb 2014, accepted on 18 Mar 2014 and first published on 19 Mar 2014


Article type: Communication
DOI: 10.1039/C4RA01345J
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Citation: RSC Adv., 2014,4, 15493-15495
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    A new route to dithia- and thiaoxacyclooctynes via Nicholas reaction

    T. Hagendorn and S. Bräse, RSC Adv., 2014, 4, 15493
    DOI: 10.1039/C4RA01345J

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