Issue 30, 2014
From the journal:

RSC Advances

Synthesis of arylacetonitrile derivatives: Ni-catalyzed reaction of benzyl chlorides with trimethylsilyl cyanide under base-free conditions†

Yasushi Satoha  and  Yasushi Obora*a  

* Corresponding authors

a Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka 564-8680, Japan
E-mail: obora@kansai-u.ac.jp
Fax: +81-6-6339-4026
Tel: +81-6-6368-0876

Abstract

We developed a simple strategy for the synthesis of arylacetonitriles from benzyl chlorides and trimethylsilyl cyanide using a Ni(cod)2/PPh3 catalyst.

Graphical abstract: Synthesis of arylacetonitrile derivatives: Ni-catalyzed reaction of benzyl chlorides with trimethylsilyl cyanide under base-free conditions

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Article information

DOI
https://doi.org/10.1039/C4RA01153H
Article type
Communication
Submitted
09 Feb 2014
Accepted
18 Mar 2014
First published
21 Mar 2014

RSC Adv., 2014,4, 15736-15739

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Synthesis of arylacetonitrile derivatives: Ni-catalyzed reaction of benzyl chlorides with trimethylsilyl cyanide under base-free conditions

Y. Satoh and Y. Obora, RSC Adv., 2014, 4, 15736 DOI: 10.1039/C4RA01153H

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