A mild process of carbon–carbon bond formation in aqueous medium: synthesis of bis(pyrrolo[2,3-d]pyrimidinyl)methanes, a novel class of compounds

Abstract

Bis(pyrrolo[2,3-d]pyrimidinyl)methanes, a novel class of compounds, were synthesized from the reaction of pyrrolo[2,3-d]pyrimidines and aldehydes/ketones via a mild process of carbon–carbon bond formation using iodine as catalyst in aqueous medium. The pure products were obtained in excellent yield via simple Buchner filtration.