Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 28, 2014
Previous Article Next Article

A protecting group free and scalable approach towards total synthesis of (−)-venlafaxine

Author affiliations

Abstract

A protecting group free asymmetric total synthesis of (−)-venlafaxine is reported. The strategy employs Sharpless epoxidation and regio-selective epoxide ring opening by an in situ generated Gilman reagent as key steps. This paper reports a 53% overall yield in 6 steps for total synthesis of (−)-venlafaxine.

Graphical abstract: A protecting group free and scalable approach towards total synthesis of (−)-venlafaxine

Back to tab navigation

Supplementary files

Article information


Submitted
30 Jan 2014
Accepted
11 Mar 2014
First published
11 Mar 2014

RSC Adv., 2014,4, 14468-14470
Article type
Communication
Author version available

A protecting group free and scalable approach towards total synthesis of (−)-venlafaxine

S. P. Chavan, K. P. Pawar and S. Garai, RSC Adv., 2014, 4, 14468
DOI: 10.1039/C4RA00840E

Social activity

Search articles by author

Spotlight

Advertisements