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Issue 28, 2014
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A protecting group free and scalable approach towards total synthesis of (−)-venlafaxine

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Abstract

A protecting group free asymmetric total synthesis of (−)-venlafaxine is reported. The strategy employs Sharpless epoxidation and regio-selective epoxide ring opening by an in situ generated Gilman reagent as key steps. This paper reports a 53% overall yield in 6 steps for total synthesis of (−)-venlafaxine.

Graphical abstract: A protecting group free and scalable approach towards total synthesis of (−)-venlafaxine

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Publication details

The article was received on 30 Jan 2014, accepted on 11 Mar 2014 and first published on 11 Mar 2014


Article type: Communication
DOI: 10.1039/C4RA00840E
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RSC Adv., 2014,4, 14468-14470

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    A protecting group free and scalable approach towards total synthesis of (−)-venlafaxine

    S. P. Chavan, K. P. Pawar and S. Garai, RSC Adv., 2014, 4, 14468
    DOI: 10.1039/C4RA00840E

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