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Issue 22, 2014
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Facile functionalization of FK506 for biological studies by the thiol–ene ‘click’ reaction

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Abstract

An efficient one-step functionalization of FK506 by the thiol–ene click (TEC) reaction is reported. This approach, which enables rapid and quantitative generation of bioactive FK1012 and FK506 derivatives, should facilitate biomedical applications of FK506-coupled molecules and expand the scope of the TEC reaction in natural product semi-synthesis.

Graphical abstract: Facile functionalization of FK506 for biological studies by the thiol–ene ‘click’ reaction

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Publication details

The article was received on 21 Dec 2013, accepted on 21 Jan 2014 and first published on 21 Jan 2014


Article type: Communication
DOI: 10.1039/C3RA47867J
Citation: RSC Adv., 2014,4, 11400-11403

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    Facile functionalization of FK506 for biological studies by the thiol–ene ‘click’ reaction

    Z. Guo, R. Zhang and F. Liang, RSC Adv., 2014, 4, 11400
    DOI: 10.1039/C3RA47867J

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