Intracellular pH-sensitive delivery CaCO3 nanoparticles templated by hydrophobic modified starch micelles

Xiaoying Ying; Chunlei Shan; Kuaikuai Jiang; Zhong Chen; Yongzhong Du

doi:10.1039/C3RA47501H

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Intracellular pH-sensitive delivery CaCO₃ nanoparticles templated by hydrophobic modified starch micelles†

Xiaoying Ying,^a Chunlei Shan,^a Kuaikuai Jiang,^a Zhong Chen*^a and Yongzhong Du*^a

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* Corresponding authors

^a College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, P. R. China
E-mail: duyongzhong@zju.edu.cn, chenzhong@zju.edu.cn
Fax: +86-0571-88208439
Tel: +86-0571-88208439

Abstract

A novel method of preparing CaCO₃ nanoparticles using a starch–octanoic acid micelle as the template was engineered. The CaCO₃ nanoparticles engineered via this method displayed stable physiochemical properties, high drug-encapsulation efficiency, low cell cytotoxicity and an intracellular pH-sensitive release profile, which indicate the potential for further applications.

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Article information

DOI: https://doi.org/10.1039/C3RA47501H
Article type: Paper
Submitted: 12 Dec 2013
Accepted: 07 Feb 2014
First published: 07 Feb 2014

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RSC Adv., 2014,4, 10841-10844

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Intracellular pH-sensitive delivery CaCO₃ nanoparticles templated by hydrophobic modified starch micelles

X. Ying, C. Shan, K. Jiang, Z. Chen and Y. Du, RSC Adv., 2014, 4, 10841 DOI: 10.1039/C3RA47501H

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