Issue 22, 2014
From the journal:

RSC Advances

A concise synthetic approach toward tamiflu (oseltamivir phosphate): cis-aziridine as the key synthon and RCM†

Subhash P. Chavan,*a   Prakash N. Chavana  and  Lalit B. Khairnara  

* Corresponding authors

a Organic Chemistry Division, National Chemical Laboratory, Dr Homi Bhabha Road, Pune-411008, Maharashtra, India
E-mail: sp.chavan@ncl.res.in
Fax: +91-20-25892629
Tel: +91-20-25902286

Abstract

The key synthon cis-aziridine has been efficiently utilised for the synthesis of oseltamivir phosphate, using Wittig olefination, Barbier addition, Mitsunobu reaction and ring closing metathesis (RCM) as key essentials.

Graphical abstract: A concise synthetic approach toward tamiflu (oseltamivir phosphate): cis-aziridine as the key synthon and RCM

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Article information

DOI
https://doi.org/10.1039/C3RA47210H
Article type
Communication
Submitted
02 Dec 2013
Accepted
07 Feb 2014
First published
11 Feb 2014

RSC Adv., 2014,4, 11417-11419

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A concise synthetic approach toward tamiflu (oseltamivir phosphate): cis-aziridine as the key synthon and RCM

S. P. Chavan, P. N. Chavan and L. B. Khairnar, RSC Adv., 2014, 4, 11417 DOI: 10.1039/C3RA47210H

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